Emergence and spread of vancomycin resistance among enterococci in Europe.

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Werner, G (Autor) Outra; Coque, TM (Autor) Outra; Hammerum, AM (Autor) Outra; Hope, R (Autor) Outra; Hryniewicz, W (Autor) Outra; Johnson, A (Autor) Outra; Klare, I (Autor) Outra; Kristinsson, KG (Autor) Outra; Leclercq, R (Autor) Outra; Lester, CH (Autor) Outra; Lillie, M (Autor) Outra; Novais, C (Autor) FFUP; Olsson Liljequist, B (Autor) Outra; Peixe, LV (Autor) FFUP; Sadowy, E (Autor) Outra; Simonsen, GS (Autor) Outra; Top, J (Autor) Outra; Vuopio Varkila, J (Autor) Outra; Willems, RJ (Autor) Outra; Witte, W (Autor) Outra; Woodford, N (Autor) Outra

Revista

Título: Eurosurveillance

Vol. 13

ISSN: 1560-7917

Editora: European Centre for Disease Prevention and Control (ECDC)

Indexação

ISI Web of Knowledge

Scopus - 375 Citações

Outras Informações

ID Authenticus: P-008-PJZ

Abstract (EN): Nowadays, six types of acquired vancomycin resistance in enterococci are known; however, only VanA and to a lesser extent VanB are widely prevalent. Various genes encode acquired vancomycin resistance and these are typically associated with mobile genetic elements which allow resistance to spread clonally and laterally. The major reservoir of acquired vancomycin resistance is Enterococcus faecium; vancomycin-resistant Enterococcus faecalis are still rare. Population analysis of E. faecium has revealed a distinct subpopulation of hospital-acquired strain types, which can be differentiated by molecular typing methods (MLVA, MLST) from human commensal and animal strains. Hospital-acquired E. faecium have additional genomic content (accessory genome) including several factors known or supposed to be virulence-associated. Acquired ampicillin resistance is a major phenotypic marker of hospital-acquired E. faecium in Europe and experience has shown that it often precedes increasing rates of VRE with a delay of several years. Several factors are known to promote VRE colonisation and transmission; however, despite having populations with similar predispositions and preconditions, rates of VRE vary all over Europe.

Idioma: Inglês

Tipo (Avaliação Docente): Científica