Naproxen availability from variable-dose and weight sustained-release tablets

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Amaral, MH (Autor) FFUP; Lobo, JMS (Autor) Outra; Ferreira, DC (Autor) FFUP

Revista

Título: Drug Development and Industrial Pharmacy

Vol. 27 Nº 8

Páginas: 221-225

ISSN: 0363-9045

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 3 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-000-X0M

DOI: 10.1081/ddc-100000240

Abstract (EN): The aim of this work was to compare the naproxen availability from hydroxypropyl methylcellulose (HPMC) matrix tablets containing the same dose and a 2-fold weight variation (160 mg of naproxen in tablets weighting 250 and 500 mg) or with the same weight and a 2-fold dose variation (500 mg of weight and 160 or 320 mg of naproxen). The 2-fold weight variation in tablets with the same dose and also the 2-fold dose variation in tablets with the same weight did not affect the naproxen release. In addition, the release rate of two tablets of the same formulation and one tablet with a 2-fold dose and weight variation was not significantly different at the first minutes of the dissolution assay.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5