Solid lipid nanoparticles (SLN) - based hydrogels as potential carriers for oral transmucosal delivery of Risperidone: Preparation and characterization studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Silva, AC (Autor) Outra; Amaral, MH (Autor) FFUP; Gonzalez Mira, E (Autor) Outra; Santos, D (Autor) Outra; Ferreira, D (Autor) FFUP

Revista

Título: Colloids and Surfaces B: Biointerfaces

Vol. 93

Páginas: 241-248

ISSN: 0927-7765

Editora: Elsevier

Indexação

ISI Web of Knowledge - 81 Citações

Scopus - 85 Citações

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Engenharia dos materiais

Outras Informações

ID Authenticus: P-002-ATG

DOI: 10.1016/j.colsurfb.2012.01.014

Abstract (EN): Two different solid lipid nanoparticles (SLN)-based hydrogels (HGs) formulations were developed as potential mucoadhesive systems for risperidone (RISP) oral transmucosal delivery. The suitability of the prepared semi-solid formulations for application on oral mucosa was assessed by means of rheological and textural analysis, during 30 days. Plastic flows with thixotropy and high adhesiveness were obtained for all the tested systems, which predict their success for the oral transmucosal application proposed. The SLN remained within the colloidal range after HGs preparation. However, after 30 days of storage, a particle size increase was detected in one type of the HGs formulations. In vitro drug release studies revealed a more pronounced RISP release after SLN hydrogel entrapment, when compared to the dispersions alone. In addition, a pH-dependent release was observed as well. The predicted in vivo RISP release mechanism was Fickian diffusion alone or combined with erosion.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8