Clavulanate-selective electrodes - application to pharmaceutical formulations

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

Pimenta, AM (Autor) Outra; Couto, CMCM (Autor) Outra; Araujo, AN (Autor) FFUP; Montenegro, MCBSM (Autor) FFUP

Revista

Título: Fresenius' Journal of Analytical Chemistry

Vol. 371

Páginas: 400-403

ISSN: 0937-0633

Editora: Springer

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 4 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-T46

DOI: 10.1007/s002160100931

Abstract (EN): The construction and assessment of a clavulanate anion-selective electrode and its application to the analysis of pharmaceutical formulations by direct potentiometry are described. The electrode. prepared without inner reference solution, was fabricated by use of a PVC membrane, with bis(triphenyl-phosphoranylidene)ammonium clavulanate as ion-exchanger dissolved in 2-nitrophenyl octyl ether as intermediate solvent and p-t-octylphenol as additive. The response of the electrode was linearly dependent on concentration within the range 2.4 x 10(-3)-1 x 10(-1) mol dm(-3) (ionic strength adjusted to 0.1 mol dm(-3)); the slope of the calibration plot was -59.4 +/-0.9 mV decade(-1) and the reproducibility +/-0.6 mV day(-1). The response time was less than 20 s. Relative errors were <3.5% when results from analysis by direct potentiometry were compared with those from the reference method.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4