Activity of anandamide (AEA) metabolic enzymes in rat placental bed

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Fonseca, BM (Autor) Outra; Battista, N (Autor) Outra; Correia da Silva, G (Autor) FFUP; Rapino, C (Autor) Outra; Maccarrone, M (Autor) Outra; Teixeira, NA (Autor) FFUP

Revista

Título: Reproductive Toxicology

Vol. 49

Páginas: 74-77

ISSN: 0890-6238

Editora: Elsevier

Indexação

ISI Web of Knowledge - 4 Citações

Scopus - 6 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-009-TTE

DOI: 10.1016/j.reprotox.2014.07.078

Abstract (EN): Endocannabinoids are endogenous lipid mediators, with anandamide (AEA) being the first member identified. It is now widely accepted that AEA influences early pregnancy events and its levels, which primarily depend on its synthesis by an N-acyl-phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) and degradation by a fatty acid amide hydrolase (FAAH), must be tightly regulated. Previous studies demonstrated that AEA levels require in situ regulation of these respective metabolic enzymes, and thus, any disturbance in AEA levels may impact maternal remodeling processes occurring during placental development. In this study, the activities of the AEA-metabolic enzymes that result in the establishment of proper local AEA levels during rat gestation were examined. Here, we demonstrate that during placentation NAPE-PLD and FAAH activities change in a temporal manner. Our findings suggest that NAPE-PLD and FAAH create the appropriate AEA levels required for tissue remodeling in the placental bed, a process essential to pregnancy maintenance.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4