Use of solid dispersions to increase stability of dithranol in topical formulations

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Marilene Estanqueiro (Autor) Outra; Jaime Conceicao (Autor) Outra; Maria Helena Amaral (Autor) FFUP; Jose Manuel S Sousa Lobo (Autor) Outra

Revista

Título: Brazilian Journal of Pharmaceutical Sciences

Vol. 50

Páginas: 583-590

ISSN: 1984-8250

Editora: Universidade de São Paulo

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 4 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências Tecnológicas > Tecnologia > Tecnologia farmacêutica

Outras Informações

ID Authenticus: P-009-YZN

DOI: 10.1590/s1984-82502014000300018

Abstract (EN): The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1: 9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1: 8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrophobic ointment in a drug/dermatological base ratio of 1: 10. The physical and mechanical properties of semisolid formulations incorporating the pure drug and the developed SD were evaluated through rheological and textural analysis. To evaluate the stability, L*a*b* color space parameters of SD and semisolid formulations, and pH of hydrophilic formulations were determined at defined times, during one month. Each sample was stored at different conditions namely, light exposure (room temperature), high temperature exposition (37 degrees C) (protected from light) and protected from light (room temperature). Despite higher values of firmness and adhesiveness, hydrophobic ointment exhibited the best rheological features compared to the oil-in-water cream, namely a shear-thinning behavior and high thixotropy. These formulations have also presented more stability, with minor changes in L*a*b* color space parameters. The results of this study indicate that is possible to conclude that the developed SD contributed to the increased stability of dithranol.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8