Anticardiolipin and antinuclear antibodies in cancer patients - A case control study

• Tipo: Artigo em Revista Científica Internacional
• Data: 2000

Autores

Armas, JB (Autor) Outra; Dantas, J (Autor) Outra; Mendonca, D (Autor) ICBAS; Farto, R (Autor) Outra; Ribeiro, M (Autor) Outra; Herrero Beaumont, G (Autor) Outra; Gouveia, J (Autor) Outra; McHugh, NJ (Autor) Outra

Revista

Título: Clinical and Experimental Rheumatology

Vol. 18

Páginas: 227-232

ISSN: 0392-856X

Editora: Pacini Editore SpA

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 24 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-001-0MW

Abstract (EN): Objective To investigate patients with cancer for the frequency of IgG and IgM aCL and ANA in comparison to a group of age- and sex-matched controls. Methods Serum levels of IgG and IgM anticardiolipin antibodies (aCL), antinuclear antibodies (ANA) and anticytoplasmic antibodies were evaluated in 145 cancer patients, including 20 patients with thromboembolic disease (TED) and compared with age- and sew-matched controls. Results Higher levels of IgG aCL were found in patients compared to controls (p < 0.02). However there appeared to be no difference in serum aCL levels between TED and the remaining cancer patients. No difference was found in the frequency of antinuclear and anticytoplasmic antibodies between patients and controls and the autoantibody presence in patients was usually not associated with concomitant autoimmune disease. Conclusion Apart from increased levels of non-thrombogenic associated IgG aCL, there was no evidence for significantly enhanced B cell autoreactivity in this large collection of cancer patients compared to controls.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6