Toxic Effects of Domoic Acid in the Seabream Sparus aurata

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Isabel Nogueira (Autor) Outra; Alexandre Lobo da Cunha (Autor) ICBAS; Antonio Afonso (Autor) ICBAS; Socorro Rivera (Autor) Outra; Joana Azevedo (Autor) Outra; Rogerio Monteiro (Autor) ICBAS; Rosa Cervantes (Autor) Outra; Ana Gago Martinez (Autor) Outra; Vitor Vasconcelos (Autor) FCUP

Revista

Título: Marine Drugs

Vol. 8

Páginas: 2721-2732

ISSN: 1660-3397

Editora: MDPI

Indexação

ISI Web of Knowledge - 10 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-2JE

DOI: 10.3390/md8102721

Abstract (EN): Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg(-1) bw. Mortality (66.67 +/- 16.67%) was only observed in dose of 9.0 mg kg(-1) bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg(-1) bw. Furthermore, the mean concentrations (+/- SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg(-1) bw were 0.61 +/- 0.01, 0.96 +/- 0.00, and 0.36 +/- 0.01 mg DA kg(-1) tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12