CYTOGENETIC FINDINGS IN 11 GASTRIC CARCINOMAS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1993

Autores

SERUCA, R (Autor) Outra; CASTEDO, S (Autor) FMUP; CORREIA, C (Autor) Outra; GOMES, P (Autor) Outra; CARNEIRO, F (Autor) FMUP; SOARES, P (Autor) Outra; DEJONG, B (Autor) Outra; SOBRINHOSIMOES, M (Autor) FMUP

Revista

Título: Cancer Genetics and Cytogenetics

Vol. 68

Páginas: 42-48

ISSN: 0165-4608

Editora: Elsevier B.V.

Indexação

ISI Web of Knowledge - 50 Citações

Scopus - 55 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-001-MWW

DOI: 10.1016/0165-4608(93)90072-t

Abstract (EN): We describe the results of the cytogenetic study of 10 primary adenocarcinomas of the stomach and one lymph node metastasis of a gastric adenocarcinoma after direct harvesting or short-term in vitro culture. All cases showed a variable number of numerical and/or structural clonal cytogenetic aberrations. Polysomy of chromosomes 2 and 20 were the most common numerical abnormalities. Rearrangements of chromosomes 1, 3, 7, and 13 were each observed in more than half the cases. Chromosomes 3 and 13 were the chromosomes more often exhibiting structural cytogenetic aberrations. In five tumors, rearrangements of chromosome 6 resulting in partial deletion of 6q were noted (common deleted region 6q21-22-->qter). The recurrent markers observed in our series were an i(8q) and an i(17q) in three and two cases, respectively. Double minutes (dmin) or homogeneously staining regions (hsr) were evident in three tumors. Contrary to the recent claim that structural abnormalities affecting 11p13-p15 were specifically involved in gastric cancer, we detected rearrangements of this region in only two cases.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7