Cytotoxic and COX-2 inhibition properties of hydroxycinnamic derivatives

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

Marques, MPM (Autor) Outra; Borges, F (Autor) FFUP; Sousa, J (Autor) Outra; Calheiros, R (Autor) Outra; Garrido, J (Autor) Outra; Gaspar, A (Autor) Outra; Antunes, F (Autor) Outra; Diniz, C (Autor) FFUP; Fresco, P (Autor) FFUP

Revista

Título: Letters in Drug Design and Discovery

Vol. 3

Páginas: 316-320

ISSN: 1570-1808

Editora: Bentham Science

Indexação

ISI Proceedings

ISI Web of Knowledge - 13 Citações

Scopus - 12 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-004-JYW

DOI: 10.2174/157018006777574212

Abstract (EN): The anticancer (cytotoxicity against human mammary gland adenocarcinoma cells) and anti-inflammatory properties (COX-2 inhibition) of the hydroxycinnamic derivatives trans-3-(3,4,5-trihydroxyphenyl)-2-propenoic acid, trans-ethyl(3,4,5-trihydroxyphenyl)-2-propenoate and diethyl 2-(3,4,5-trihydroxy-phenylmethylene)malonate were screened. Data point out a putative correlation between anti-inflammatory and anticancer properties and suggest hydroxycinnamic derivatives as promising lead compounds for the development of anti-inflammatory/chemopreventive agents.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5