On complex I and other NADH : Ubiquinone reductases of Neurospora crassa mitochondria

• Tipo: Artigo em Revista Científica Internacional
• Data: 2001

Autores

videira, a (Autor) ICBAS; duarte, m (Autor) ICBAS

Revista

Título: Journal of Bioenergetics and Biomembranes

Vol. 33

Páginas: 197-203

ISSN: 0145-479X

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 31 Citações

Scopus - 31 Citações

Outras Informações

ID Authenticus: P-000-VC7

DOI: 10.1023/A:1010778802236

Abstract (EN): The mitochondrial complex I is the first component of the respiratory chain coupling electron transfer from NADH to ubiquinone to proton translocation across the inner membrane of the organelle. The enzyme from the fungus Neurospora crassa is similar to that of other organisms in terms of protein and prosthetic group composition, structure, and function. It contains a high number of polypeptide subunits of dual genetic origin. Most of its subunits were cloned, including those binding redox groups. Extensive gene disruption experiments were conducted, revealing many aspects of the structure, function, and biogenesis of complex I. Complex I is essential for the sexual phase of the life cycle of N. crassa, but not for the asexual stage. In addition to complex I, the fungal mitochondria contain at least three nonproton-pumping alternative NAD(P)H dehydrogenases feeding electrons to the respiratory chain from either matrix or cytosolic substrates.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7