A KINETIC-STUDY OF THE RATE OF FORMATION OF DOPAMINE, 3,4-DIHYDROXYPHENYLACETIC ACID (DOPAC) AND HOMOVANILLIC-ACID (HVA) IN THE BRAIN OF THE RAT - IMPLICATIONS FOR THE ORIGIN OF DOPAC

• Tipo: Artigo em Revista Científica Internacional
• Data: 1990

Autores

SOARESDASILVA, P (Autor) Outra; GARRETT, MC (Autor) FMUP

Revista

Título: Neuropharmacology

Vol. 29

Páginas: 869-874

ISSN: 0028-3908

Editora: Elsevier

Indexação

ISI Web of Knowledge - 50 Citações

ISI Web of Science

Scopus - 47 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde > Ciências farmacológicas > Farmacologia clínica

Outras Informações

ID Authenticus: P-001-RGN

DOI: 10.1016/0028-3908(90)90135-e

Resumo (PT): .

Abstract (EN): The rates of disappearance of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the brain of rats treated with the tyrosine hydroxylase inhibitor ¿-methyl-p-tyrosine were measured. Levels of dopamine, DOPAC and HVA in tissue were quantified in the striatum, nucleus accumbens and frontal cortex of the rat by means of high pressure liquid chromatography with electrochemical detection. Rats were sacrificed 1, 2 or 3 hr after the administration of ¿-methyl-p-tyrosine (200 mg/kg, i.p.). Levels of dopamine, DOPAC and HVA in tissue were logarithmically transformed, plotted against the duration of inhibition of tyrosine hydroxylase and the rate constant of the decline of dopamine and of its metabolites calculated. The rate constant of decline of DOPAC in each area of brain studied was found to be greater than that for dopamine. The rate constant for the decline of dopamine was found to be greater in areas of the brain presenting the largest DOPAC/dopamine tissue ratios (frontal cortex > nucleus accumbens > striatum). The present results suggest that a substantial amount of DOPAC in brain derives from a newly formed pool of dopamine. © 1990.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6