What is in the pipeline for new treatments for bladder pain syndrome/ interstitial cystitis?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2024

Autores

Dias, D (Autor) Outra; Mendes, PA (Autor) Outra; Paulo Dinis (Autor) FMUP; Pinto, RA (Autor) Outra

Revista

Título: Current Opinion in Urology

Vol. 34

Páginas: 58-63

ISSN: 0963-0643

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-010-0XF

DOI: 10.1097/mou.0000000000001159

Abstract (EN): Purpose of reviewDespite available treatments, many bladder pain syndrome/interstitial cystitis (BPS/IC) patients continue to have poor quality of life. Thus, there is an urge for new therapies. Our manuscript aims to review papers about BPS/IC treatments published in the last 2 years.Recent findingsDuring this period, several treatments were tested, most of them new and others combining treatments already used. Pentosan polysulfate, interleukin 1 antagonist, low energy shock wave, physical therapy, hypnosis, acupuncture, clorpactin, dimethyl sulfoxide and hyaluronic acid plus botulinum toxin-A showed positive results. ASP3652 and lidocaine-releasing intravesical systems failed to prove their efficacy.SummaryValidation of these studies is arduous due to the broad spectre of BPS/IC phenotypes, small number of patients enrolled, distinct outcome measures and short-term follow-up. It is also important to highlight that some authors combined therapies, and others split central and peripheric phenotypes before treatment. Therefore, soon, phenotyping and combining therapies with a step-by-step approach will be needed in BPS/IC treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6