Directly compressed mini matrix tablets containing ibuprofen: Preparation and evaluation of sustained release

• Tipo: Artigo em Revista Científica Internacional
• Data: 2006

Autores

lopes, cm (Autor) Outra; manuel, j (Autor) Outra; lobo, s (Autor) Outra; costa, p (Autor) FFUP; pinto, jf (Autor) Outra

Revista

Título: Drug Development and Industrial Pharmacy

Vol. 32 Nº 1

Páginas: 95-106

ISSN: 0363-9045

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 27 Citações

Scopus - 39 Citações

Outras Informações

ID Authenticus: P-004-PHG

DOI: 10.1080/03639040500388482

Abstract (EN): Directly compressed mini tablets were produced containing either hydroxypropylmethylcellulose (HPMC) or ethylcellulose (EC) as release controlling agent. The dynamics of water uptake and erosion degree of polymer were investigated. By changing the polymer concentration, the ibuprofen release was modified. In identical quantities, EC produced a greater sustaining release effect than HPMC. Different grades of viscosity of HPMC did not modify ibuprofen release. For EC formulations, the contribution of diffusion was predominant in the ibuprofen release process. For HPMC preparations, the drug release approached zero-order during a period of 8 h. For comparative purposes, tablets with 10 mm diameter were produced.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12