Evaluation of mathematical models describing drug release from estradiol transdermal systems

• Tipo: Artigo em Revista Científica Internacional
• Data: 2003

Autores

costa, p (Autor) FFUP; lobo, jms (Autor) Outra

Revista

Título: Drug Development and Industrial Pharmacy

Vol. 29 Nº 1

Páginas: 89-97

ISSN: 0363-9045

Editora: Taylor & Francis

Indexação

ISI Web of Knowledge - 64 Citações

Scopus - 71 Citações

Outras Informações

ID Authenticus: P-000-JGM

DOI: 10.1081/ddc-120016687

Abstract (EN): The in vitro release profiles of 13 patches of estradiol (from five marketed products) were determined by the paddle-over-disk method. The transdermal systems were membrane-controlled type or matrix diffusion-controlled type. The estradiol content of test aliquots of the dissolution medium was determined by HPLC. To analyze the release mechanism, several release models were tested such as zero order, first order, Higuchi, Weibull, Korsmeyer-Peppas, and Makoid-Banakar. The release profiles showed that the drug was released at a constant rate for three patches. The drug-release rate from the other 10 patches was not constant, and diminished with the square-root of time (Higuchi model).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9