Inhibitory effect of Lavandula viridis on Fe2+-induced lipid peroxidation, antioxidant and anti-cholinesterase properties

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Patricia Costa (Autor) Outra; Sandra Goncalves (Autor) Outra; Paula B Andrade (Autor) FFUP; Patricia Valentao (Autor) FFUP; Anabela Romano (Autor) Outra

Revista

Título: Food Chemistry

Vol. 126 Nº 3

Páginas: 1779-1786

ISSN: 0308-8146

Editora: Elsevier

Indexação

ISI Web of Knowledge - 31 Citações

Scopus - 41 Citações

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

CORDIS: Ciências da Saúde > Ciências farmacológicas > Farmacognosia

Outras Informações

ID Authenticus: P-002-QG3

DOI: 10.1016/j.foodchem.2010.12.085

Resumo (PT): In this research, the total phenolic content of a Lavandula viridis methanol extract was evaluated and the phenolic identification and quantification was assessed. Rosmarinic acid and luteolin-7-O-glucoside were the two major compounds identified by HPLC–DAD (ca. 39 and 13 g/kg, respectively). This extract showed a strong antioxidant activity in ORAC (2858.39 ± 70.97 μmolTE/gextract) and TEAC (967.18 ± 22.57 μmolTE/gextract) assays, as well as Fe2+ chelating and OH scavenging abilities. Furthermore, the extract prevented Fe2+-induced lipid peroxidation, by reducing MDA content in mouse brains (in vitro), and inhibited AChE and BChE activities both in vitro and in vivo. These findings demonstrate that the methanol extract from L. viridis is a potential source of natural antioxidants and cholinesterase inhibitors. Research highlights ► Rosmarinic acid and luteolin 7-O-glucoside are the major compounds identified. ► Extract exhibited strong antioxidant activity through different mechanisms. ► Prevention of Fe2+-induced lipid peroxidation in mouse brains was observed. ► The inhibition of cholinesterases activities was demonstrated in vitro and in vivo. <br> <br> Keywords: Free radicals; Antioxidants; Fe2+ chelation; Lipid peroxidation; Anti-cholinesterase; Alzheimer’s disease <br> <a target="_blank" href="http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T6R-51SFK5K-6&_user=2460038&_coverDate=06%2F15%2F2011&_rdoc=39&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info(%23toc%235037%232011%23998739995%232886758%23FLA%23display%23Volume)&_cdi=5037&_sort=d&_docanchor=&_ct=74&_acct=C000057398&_version=1&_urlVersion=0&_userid=2460038&md5=ac4bf9bcd563d22261287eb0ee4bc037&searchtype=a"> Texto integral</a> <br> <br>

Abstract (EN): In this research, the total phenolic content of a Lavandula viridis methanol extract was evaluated and the phenolic identification and quantification was assessed. Rosmarinic acid and luteolin-7-O-glucoside were the two major compounds identified by HPLC-DAD (ca. 39 and 13 g/kg, respectively). This extract showed a strong antioxidant activity in ORAC (2858.39 +/- 70.97 mu mol(TE)/g(extract)) and TEAC (967.18 +/- 22.57 mu mol(TE)/g(extract)) assays, as well as Fe2+ chelating and (OH)-O-center dot scavenging abilities. Furthermore, the extract prevented Fe2+-induced lipid peroxidation, by reducing MDA content in mouse brains (in vitro), and inhibited AChE and BChE activities both in vitro and in vivo. These findings demonstrate that the methanol extract from L viridis is a potential source of natural antioxidants and cholinesterase inhibitors.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8