Detection of subclinical microvascular changes in systemic lupus erythematous using optical coherence tomography angiography: A systematic review and meta-analysis

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Ferreira, A (Autor) FMUP; Vieira, RJ (Autor) FMUP; Furtado, MJ (Autor) Outra; Lume, M (Autor) Outra; Andrade, JP (Autor) FMUP; Menéres, P (Autor) Outra

Revista

Título: Survey of Ophthalmology

Vol. 68

Páginas: 1115-1128

ISSN: 0039-6257

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-VXY

DOI: 10.1016/j.survophthal.2023.07.008

Abstract (EN): Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune connective tissue disease that affects several vascular territories. We sought to assess the role of optical coherence tomography angiography in detecting subclinical microvascular alterations in SLE patients. PubMed, Scopus, and Web of Science databases were systematically searched until January 21, 2023. Studies using optical coherence tomography angiography as a primary diagnostic method to evaluate the macular microvasculature of SLE patients versus healthy controls were included. Primary outcomes were macular vessel density and foveal zone parameters. A meta-analysis was performed using a random-effects model. Of 301 screened abstracts, 15 were found eligible, enrolling 1,246 eyes from 1,013 patients. SLE patients presented a reduction of macular vessel density at both plexuses in all zones (whole scan, fovea, parafovea, and perifovea), and of foveal density compared with healthy controls. No differences were found at foveal avascular zone parameters. SLE patients presented a reduction of macular vessel density without signs or symptoms of SLE ocular involvement. Optical coherence tomography angiography application for the assessment of subclinical microvascular changes needs to be elucidated with longitudinal studies.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14