Synthesis and evaluation of alpha-, beta-glucosidase inhibition of 1-N-carboxamide-1-azafagomines and 5-epi-1-azafagomines

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Mendes, R (Autor) Outra; Duarte, VCM (Autor) Outra; Fortes, AG (Autor) Outra; Alves, MJ (Autor) Outra

Revista

Título: Carbohydrate Research

Vol. 395

Páginas: 52-57

ISSN: 0008-6215

Editora: Elsevier

Indexação

ISI Web of Knowledge - 3 Citações

Scopus - 5 Citações

Outras Informações

ID Authenticus: P-009-PW7

DOI: 10.1016/j.carres.2014.06.015

Abstract (EN): 1-N-Carboxamide 1-azafagomines and 5-epi-1-azafagomines were obtained from 1-azafagomine and 5-epi-1-azafagomine. The hydroxyl groups and the N-2 pyridazine position were protected prior to reaction with different isocyanates to form ureas. Protective groups were removed leading to the target compounds in 18-23% global yields. Final compounds were tested towards alpha- and beta-glucosidases.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6