Biomechanical Properties of Vaginal Tissue in Women with Pelvic Organ Prolapse

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Pedro Martins (Autor) FEUP; Agnaldo Lopes Silva Filho (Autor) Outra; Andrea Moura R M Rodrigues Maciel da Fonseca (Autor) Outra; Agostinho Santos (Autor) Outra; Liliana Santos (Autor) Outra; Teresa Mascarenhas (Autor) FMUP; Renato M N Natal Jorge (Autor) FEUP; Antonio J M Ferreira (Autor) FEUP

Revista

Título: Gynecologic and Obstetric Investigation

Vol. 75

Páginas: 85-92

ISSN: 0378-7346

Editora: Karger

Indexação

ISI Web of Knowledge - 37 Citações

ISI Web of Science

Scopus - 36 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Ginecologia

Outras Informações

ID Authenticus: P-002-1EC

DOI: 10.1159/000343230

Abstract (EN): Background/Aims: To compare biomechanical properties of vaginal tissues between women with and without pelvic organ prolapse (POP) and investigate factors that may influence these properties. Methods: Forty patients submitted to POP surgery and 15 non-POP cadavers were evaluated. The tissue was excised from anterior and posterior middle third vagina. The biomechanical properties considered were stiffness (E) and maximum stress (S-max), and they were evaluated by means of uniaxial tension tests. Results: POP patients were associated with higher values of E (13.1 +/- 0.8 vs. 9.5 +/- 0.7 MPa; p < 0.001) and S-max (5.3 +/- 0.5 vs. 3.2 +/- 0.9 MPa; p < 0.001) in the anterior vaginal wall compared to the posterior wall. In contrast, non-POP women presented lower values of E (6.9 +/- 1.1 vs. 10.5 +/- 1.0 MPa; p = 0.01) and S-max (2.6 +/- 0.4 vs. 3.5 +/- 0.4 MPa; p = 0.043) in the anterior wall. The occurrence of POP was the only independent predictor of higher values of E and S-max in anterior vaginal samples (p = 0.003 and p = 0.008, respectively). Women with severe anterior vaginal prolapse presented higher levels of E and S-max in the anterior sample compared to those with lower POP stages (p = 0.001 and p = 0.01; respectively). Conclusion:Women with POP present significant changes of biomechanical properties in the vagina. Copyright (C) 2012 S. Karger AG, Basel

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8