GLP-1 Increases Circulating Leptin Levels in Truncal Vagotomized Rats

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Morais, T (Autor) Outra; Pereira, SS (Autor) ICBAS; Andrade, S (Autor) Outra; Neves, D (Autor) Outra; Guimaraes, M (Autor) Outra; Nora, M (Autor) Outra; Carreira, MC (Autor) Outra; Casanueva, FF (Autor) Outra; Monteiro, M (Autor) ICBAS

Revista

Título: Biomedicines

Vol. 11

Página Final: 1322

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-B5R

DOI: 10.3390/biomedicines11051322

Abstract (EN): GLP-1 is a gastro-intestinal hormone acting within the gut/brain axis for energy balance regulation. We aimed to evaluate the role of the vagus nerve in whole-body energy homeostasis and in mediating GLP-1 effects. For this, rats submitted to truncal vagotomy and sham-operated controls underwent a comprehensive evaluation, including eating behavior, body weight, percentage of white (WAT) and brown adipose tissue (BAT), resting energy expenditure (REE) and acute response to GLP-1. Truncal vagotomized rats had significantly lower food intake, body weight, body weight gain, WAT and BAT, with a higher BAT/WAT ratio, but no significant difference in REE when compared to controls. Vagotomized rats also had significantly higher fasting ghrelin and lower glucose and insulin levels. After GLP-1 administration, vagotomized rats depicted a blunted anorexigenic response and higher plasma leptin levels, as compared to controls. However, in vitro stimulation of VAT explants with GLP-1 resulted in no significant changes in leptin secretion. In conclusion, the vagus nerve influences whole-body energy homeostasis by modifying food intake, body weight and body composition and by mediating the GLP-1 anorectic response. The higher leptin levels in response to acute GLP-1 administration observed after truncal vagotomy suggest the existence of a putative GLP-1-leptin axis that relies on the integrity of gut-brain vagal pathway.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13