Two Surface Activation Strategies to Functionalize Cotton Fibers with Cys-LC-LL-37 Antibacterial Peptide

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Mouro, C (Autor) Outra; Pedrosa, M (Autor) FEUP; Vaz, J (Autor) Outra; Gouveia, I (Autor) Outra

Revista

A Revista está pendente de validação pelos Serviços Administrativos.

Título: AATCC JOURNAL OF RESEARCH

Vol. 1

Páginas: 27-33

ISSN: 2330-5517

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-00K-TF9

DOI: 10.14504/ajr.1.6.4

Abstract (EN): This investigation aimed to determine which of two surface activation methods, N,N'-carbonyldiimidazole (CDI) or 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), allowed more effective bonding of Cys-LC-LL-37, an antimicrobial peptide (AMP), onto cotton fibers and which one presented greater antimicrobial activity. The antibacterial effect of the TEMPO-activated cotton functionalized with Cys-LC-LL-37 was more effective against Staphylococcus aureus, while the CDI-activated cotton covalently bonded to Cys-LC-LL-37 was more effective against Klebsiella pneumoniae. CDI-activated cotton retained a higher percentage of the AMP, making this bioactive strategy the choice for development of AMP antimicrobial textiles.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7