Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab

• Tipo: Artigo em Revista Científica Internacional
• Data: 2017

Autores

Peixoto, A (Autor) Outra; Coelho, R (Autor) Outra; Maia, T (Autor) Outra; Sarmento A (Autor) FMUP; Magro, F (Autor) Outra; Macedo G (Autor) FMUP

Revista

Título: ACG Case Reports Journal

Vol. 4

Página Final: e46

ISSN: 2326-3253

Editora: American College of Gastroenterology

Indexação

ISI Web of Knowledge - 4 Citações

Outras Informações

ID Authenticus: P-00N-1HW

DOI: 10.14309/crj.2017.46

Abstract (EN): Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. The authors report an X-linked CGD female carrier who presented during adulthood with diarrhea and colorectal ulcers, with high impairment of quality of life. Induction with infliximab 5 mg/kg (weeks 0, 2, and 6) with infectious prophylaxis was initiated. She continued infliximab 5 mg/kg every 8 weeks with complete symptomatic response at 15 months.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3