Thyroid Cancer: The Quest for Genetic Susceptibility Involving DNA Repair Genes

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Santos, LS (Autor) Outra; Gomes, BC (Autor) Outra; Bastos, HN (Autor) FMUP; Gil, OM (Autor) Outra; Azevedo, AP (Autor) Outra; Ferreira, TC (Autor) Outra; Limbert, E (Autor) Outra; Silva, SN (Autor) Outra; Rueff, J (Autor) Outra

Revista

Título: Genes

Vol. 10

Página Final: 586

ISSN: 2073-4425

Editora: MDPI

Indexação

ISI Web of Knowledge - 5 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00Q-ZPE

DOI: 10.3390/genes10080586

Abstract (EN): The incidence of thyroid cancer (TC), particularly well-differentiated forms (DTC), has been rising and remains the highest among endocrine malignancies. Although ionizing radiation (IR) is well established on DTC aetiology, other environmental and genetic factors may also be involved. DNA repair single nucleotide polymorphisms (SNPs) could be among the former, helping in explaining the high incidence. To further clarify the role of DNA repair SNPs in DTC susceptibility, we analyzed 36 SNPs in 27 DNA repair genes in a population of 106 DTCs and corresponding controls with the aim of interpreting joint data from previously studied isolated SNPs in DNA repair genes. Significant associations with DTC susceptibility were observed for XRCC3 rs861539, XPC rs2228001, CCNH rs2230641, MSH6 rs1042821 and ERCC5 rs2227869 and for a haplotype block on chromosome 5q. From 595 SNP-SNP combinations tested and 114 showing relevance, 15 significant SNP combinations (p < 0.01) were detected on paired SNP analysis, most of which involving CCNH rs2230641 and mismatch repair variants. Overall, a gene-dosage effect between the number of risk genotypes and DTC predisposition was observed. In spite of the volume of data presented, new studies are sought to provide an interpretability of the role of SNPs in DNA repair genes and their combinations in DTC susceptibility.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 31