Myocardial oedema: pathophysiological basis and implications for the failing heart

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Vasques Novoa, F (Autor) FMUP; Angelico Goncalves, A (Autor) Outra; Alvarenga, JMG (Autor) Outra; Nobrega, J (Autor) Outra; Cerqueira, RJ (Autor) FMUP; Mancio, J (Autor) FMUP; Leite-Moreira AF (Autor) FMUP; Roncon-Albuquerque R Jr (Autor) FMUP

Revista

Título: ESC heart failure

Editora: The Heart Failure Association of the European Society of Cardiology

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 16 Citações

Outras Informações

ID Authenticus: P-00W-4CQ

DOI: 10.1002/ehf2.13775

Abstract (EN): Myocardial fluid homeostasis relies on a complex interplay between microvascular filtration, interstitial hydration, cardiomyocyte water uptake and lymphatic removal. Dysregulation of one or more of these mechanisms may result in myocardial oedema. Interstitial and intracellular fluid accumulation disrupts myocardial architecture, intercellular communication, and metabolic pathways, decreasing contractility and increasing myocardial stiffness. The widespread use of cardiac magnetic resonance enabled the identification of myocardial oedema as a clinically relevant imaging finding with prognostic implications in several types of heart failure. Furthermore, growing experimental evidence has contributed to a better understanding of the physical and molecular interactions in the microvascular barrier, myocardial interstitium and lymphatics and how they might be disrupted in heart failure. In this review, we summarize current knowledge on the factors controlling myocardial water balance in the healthy and failing heart and pinpoint the new potential therapeutic avenues.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19