The influence of the gastric microbiota in gastric cancer development

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Pereira Marques, J (Autor) Outra; Ferreira, RM (Autor) Outra; Machado JC (Autor) FMUP; Figueiredo C (Autor) FMUP

Revista

Título: Best Practice and Research in Clinical Gastroenterology

Vol. 50-51

ISSN: 1521-6918

Editora: Elsevier

Indexação

ISI Web of Knowledge - 2 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00T-M98

DOI: 10.1016/j.bpg.2021.101734

Abstract (EN): Colonization of the stomach by Helicobacter pylori is the trigger for a series of gastric mucosal changes that culminate in gastric cancer. Infection with this bacterium is considered the major risk factor for this malignancy. The introduction of high-throughput sequencing technologies coupled to advanced computational pipelines offered an improved understanding of the microbiome, and it is now currently accepted that, besides H. pylori, the stomach harbours a complex microbial community. While it is well established that H. pylori plays a central role in gastric carcinogenesis, the significance of the non H. pylori microbiota is yet to be clarified. This review will address the state of the art on the relationship between the gastric microbiota and gastric cancer development, and identify areas where additional research is needed before translating microbiome research into preventive and therapeutic strategies to reduce gastric cancer burden.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6