Expression and prognostic significance of CK19 in canine malignant mammary tumours

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

Gama, A (Autor) Outra; Alves, A (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Veterinary Journal

Vol. 184

Páginas: 45-51

ISSN: 1090-0233

Editora: Elsevier

Indexação

ISI Web of Knowledge - 17 Citações

Scopus - 20 Citações

Outras Informações

ID Authenticus: P-003-861

DOI: 10.1016/j.tvjl.2009.02.001

Abstract (EN): Expression of the luminal cytokeratin CK19 was examined in 102 canine mammary carcinomas by immunohistochemical analysis and associated with known expression of oestrogen receptor (ER), basal/myoepithelial cell markers, proliferation and survival. Negative staining for CK19 was present in 23.5% of tumours and was associated with histological type, grade, invasiveness, Ki67 index and expression of basal/myoepithelial cell markers. Positive staining for CK19 was associated with ER expression. Reduced expression of CK19 was associated with both shorter overall and disease-free survival rates; however, CK19 was not an independent prognostic factor in multivariate analysis. Reduced expression of CK19 in canine mammary carcinomas is related to an aggressive phenotype and may play a role in tumour progression.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 7