Synthesis of regioisomeric functionalized benzodifurans and angelicins

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Elias Quezada (Autor) FCUP; Delogu, G (Autor) Outra; Vina, D (Autor) Outra; Santana, L (Autor) Outra; Podda, G (Autor) Outra; Matos, MJ (Autor) Outra; Picciau, C (Autor) Outra

Revista

Título: Helvetica Chimica Acta

Vol. 92

Páginas: 1309-1314

ISSN: 0018-019X

Editora: Wiley-Blackwell

Indexação

Scopus - 2 Citações

Outras Informações

ID Authenticus: P-007-QMS

DOI: 10.1002/hlca.200800421

Abstract (EN): Arenofurans have important biological and pharmacological activities. Compared to benzofurans, the reports on the synthesis of benzodifurans are rather limited. Here, we report the synthesis of a linear and an angular 3,3¿-bis(carboxymethyl)substituted benzodifuran and 4¿- carboxymethyl-substituted angelicins from phloroglucinol, using 4-halomethyl-substituted dipyrones as key intermediates in the synthetic route. This strategy shows that the stability of a pyrone ring depends on the type of substituent at C(4) and the conditions used. © 2009 Verlag Helvetica Chimica Acta AG.

Idioma: Inglês

Tipo (Avaliação Docente): Científica