In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

• Tipo: Artigo em Revista Científica Internacional
• Data: 2020

Autores

Fonseca Gomes, J (Autor) Outra; Joana A Loureiro (Autor) FEUP; Tanqueiro, SR (Autor) Outra; Mouro, FM (Autor) Outra; Ruivo, P (Autor) Outra; Carvalho, T (Autor) Outra; Sebastiao, AM (Autor) Outra; Diogenes, MJ (Autor) Outra; Maria do Carmo Pereira (Autor) FEUP

Revista

Título: International Journal of Nanomedicine

Vol. 15

Páginas: 8609-8621

ISSN: 1176-9114

Editora: Dove Medical Press

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 4 Citações

Outras Informações

ID Authenticus: P-00T-086

DOI: 10.2147/ijn.s267007

Abstract (EN): Introduction: Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected. Methods: We screened different NPs, polymeric and lipid-based, in a repeated-dose toxicity study, to evaluate the safety and tissue distribution of promising nanocarriers to be used in the treatment of long-lasting diseases. Results: After administrating 24 high concentrated doses of the selected NPs intraperitoneally (i.p.) (3 times a week for 2 months), animals have presented NPs accumulation in different tissues. However, neither toxicity, bodyweight changes nor clinical signs of disease were observed. Discussion: This work demonstrates no general adverse effects upon the studied NPs repeated-dose exposure, indicating the most promising NPs to be used in the different therapeutic circumstances, which may be useful in chronic diseases treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13