Cystitis is associated with TRPVIb-downregulation in rat dorsal root ganglia

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Charrua A. (Autor) FCNAUP; reguenga, c (Autor) FMUP; Paule, CC (Autor) Outra; Nagy, I (Autor) Outra; Francisco Cruz (Autor) FMUP; António Avelino Silva (Autor) FMUP

Revista

Título: NeuroReport

Vol. 19 Nº 15

Páginas: 1469-1472

ISSN: 0959-4965

Editora: Wolters Kluwer Health

Indexação

Scopus - 17 Citações

Outras Informações

ID Authenticus: P-00F-HZ3

DOI: 10.1097/wnr.0b013e32830f1e73

Abstract (EN): The recently identified splice variant of the transient receptor vanilloid type I (TRPVI) molecule, TRPVIb, produces a negative-dominant effect on the responsiveness of theTRPVI channel, which is increased by peripheral inflammatory processes. Here, we studied, using real-time polymerase chain reaction, whether cyclophosphamide injection-evoked cystitis is associated with altered TRPVI/TRPVIb expression in the L5-L6 dorsal root ganglia, which innervate the urinary bladder. We found that while TRPVI mRNA expression was unchanged, the amount of TRPVIb transcript was significantly reduced in L5-L6 dorsal root ganglia during cystitis. These data indicate that peripheral inflammatory events induce changes inTRPVIb expression in primary sensory neurons, which may result in increased responsiveness of the TRPVI channel. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Idioma: Inglês

Tipo (Avaliação Docente): Científica