Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Fernandes, C (Autor) Outra; Soares, P (Autor) Outra; Gaspar, A (Autor) Outra; Martins, D (Autor) Outra; Gomes, LR (Autor) Outra; Low, JN (Autor) Outra; Fernanda Borges (Autor) FCUP

Revista

Título: Tetrahedron Letters

Vol. 57

Páginas: 3006-3010

ISSN: 0040-4039

Editora: Elsevier

Indexação

ISI Web of Knowledge - 7 Citações

Scopus - 7 Citações

Outras Informações

ID Authenticus: P-00K-ST7

DOI: 10.1016/j.tetlet.2016.05.096

Abstract (EN): The development of new chemical entities represents an important challenge in pharmaceutical industry, being the use of privileged scaffolds for library design and drug discovery a valuable approach. Among the panoply of privileged structures, our research group has focused its attention on the chromone (4H-benzopyran-4-one) scaffold due to its chemical versatility and ability to bind to multiple targets. With this endeavour we report an expedite two-step procedure for the synthesis of novel 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester. The new chromones were synthesized by a C-C Suzuki cross-coupling microwave-assisted reaction, using Pd(OAc)(2) as a catalyst, and a classic Claisen condensation followed by an intramolecular cyclization process.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5