IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages

• Tipo: Artigo em Revista Científica Internacional
• Data: 2015

Autores

Cruz, A (Autor) Outra; Ludovico, P (Autor) Outra; Torrado, E (Autor) Outra; Gama, JB (Autor) Outra; Sousa, J (Autor) Outra; Gaifem, J (Autor) Outra; Appelberg, R (Autor) ICBAS; Rodrigues, F (Autor) Outra; Cooper, AM (Autor) Outra; Pedrosa, J (Autor) Outra; Saraiva, M (Autor) Outra; Castro, AG (Autor) Outra

Revista

Título: Frontiers In Immunology

Vol. 6

ISSN: 1664-3224

Editora: Frontiers Media

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00G-R7V

DOI: 10.3389/fimmu.2015.00498

Abstract (EN): The fate of infected macrophages is a critical aspect of immunity to mycobacteria. By depriving the pathogen of its intracellular niche, apoptotic death of the infected macrophage has been shown to be an important mechanism to control bacterial growth. Here, we show that IL-17 inhibits apoptosis of Mycobacterium bovis BCG- or Mycobacterium tuberculosis-infected macrophages thus hampering their ability to control bacterial growth. Mechanistically, we show that IL 17 inhibits p53, and impacts on the intrinsic apoptotic pathway, by increasing the BcI2 and decreasing Bax expression, decreasing cytochrome c release from the mitochondria, and inhibiting caspase-3 activation. The same effect of IL 17 was observed in infected macrophages upon blockade of p53 nuclear translocation. These results reveal a previously unappreciated role for the IL-17/p53 axis in the regulation of mycobacteria-induced apoptosis and can have important implications in a broad spectrum of diseases where apoptosis of the infected cell is an important host defense mechanism.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8