Bovine papillomavirus: opening new trends for comparative pathology

• Tipo: Artigo em Revista Científica Internacional
• Data: 2014

Autores

Rui M. Gil da Costa (Autor) FEUP; Rui Medeiros (Autor) ICBAS

Revista

Título: Archives of Virology

Vol. 159 Nº 2

Páginas: 191-198

ISSN: 0304-8608

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 0 Citações

Projetos Associados

UI0511 - PROJECTO ESTRATÉGICO - UI 511 - 2013-2014

Outras Informações

ID Authenticus: P-009-6RF

DOI: 10.1007/s00705-013-1801-9

Abstract (EN): For many years, research on bovine papillomavirus (BPV) has contributed to the understanding of papillomavirus-induced pathology in humans and animals. The present review shows how recent studies on BPV keep providing evidence concerning key points in viral infection, such as the expression of viral proteins in lymphocytes and the occurrence of productive infections of the placenta. Studies on BPV-induced tumours also provide important information concerning the mechanisms of oncogenesis and immune evasion, as in the cases of connexin 43 down-regulation with loss of intercellular gap junctions and Toll-like receptor 4 (TLR4) down-regulation in equine sarcoids. The biological functions of viral proteins are also being further clarified, as in the case of E2, which was recently shown to load BPV genomes into host chromosomes during the S phase, a process mediated by the ChlR1 protein. In the near future, the ongoing efforts to characterize and classify additional emerging BPV types are likely to broaden even further the possibilities for research.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8