A slow acetylator genotype associated with an increased risk of advanced cervical cancer

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Costa, S (Autor) Outra; Medeiros, R (Autor) Outra; Vasconcelos, A (Autor) Outra; Pinto, D (Autor) Outra; Lopes, C (Autor) ICBAS

Revista

Título: Journal of Cancer Research and Clinical Oncology

Vol. 128

Páginas: 678-682

ISSN: 0171-5216

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 25 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-000-M7M

DOI: 10.1007/s00432-002-0391-9

Abstract (EN): Purpose: Human papillomavirus (HPV) is the major etiological agent associated with cervical cancer. However, other risk factors have been indicated, including carcinogen exposure, oral contraceptive usage, certain nutritional deficiencies, and genetic factors. N-acetyltransferase 2 (NAT2) has an important role in the metabolism of several carcinogens. NAT2 polymorphism modulates the activity of the enzyme, by activation, via O-acetylation, or through detoxification, via N-acetylation. This case-control study was designed to evaluate the association between NAT2 polymorphism and genetic susceptibility to cervical cancer. Methods: Genomic DNA was obtained from 125 women with advanced cervical cancer and 170 healthy women. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphisms) was used to analyse two common mutant alleles at NAT2 loci. Results: The NAT2*6/NAT2*6 genotype, which corresponds to a slow acetylator genotype, was found to be associated with a 3.41-fold (95% CI: 1.35-8.94; P = 0.007) increase in the risk of cervical cancer. For the entire case groups the proportion of cervical cancer cases attributable (attributable proportion) to the NAT2*6/NAT2*6 genotype was 10.2%. Conclusions: The results reported in this study suggest that NAT2 polymorphism is a genetic susceptibility factor involved in the carcinogenesis of cervical cancer, and also that the analysis of the allelic profile of populations in different geographic locations may help to understand the incidence of cervical cancer worldwide.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5