Toxic Effects of Domoic Acid in the Seabream Sparus aurata

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Isabel Nogueira (Author) Other; Alexandre Lobo da Cunha (Author) ICBAS; Antonio Afonso (Author) ICBAS; Socorro Rivera (Author) Other; Joana Azevedo (Author) Other; Rogerio Monteiro (Author) ICBAS; Rosa Cervantes (Author) Other; Ana Gago Martinez (Author) Other; Vitor Vasconcelos (Author) FCUP

Journal

Title: Marine Drugs

Vol. 8

Pages: 2721-2732

ISSN: 1660-3397

Publisher: MDPI

Indexing

ISI Web of Knowledge - 10 Citations

Scopus - 15 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-003-2JE

DOI: 10.3390/md8102721

Abstract (EN): Neurotoxicity induced in fish by domoic acid (DA) was assessed with respect to occurrence of neurotoxic signs, lethality, and histopathology by light microscopy. Sparus aurata were exposed to a single dose of DA by intraperitoneal (i.p.) injection of 0, 0.45, 0.9, and 9.0 mg DA kg(-1) bw. Mortality (66.67 +/- 16.67%) was only observed in dose of 9.0 mg kg(-1) bw. Signs of neurological toxicity were detected for the doses of 0.9 and 9.0 mg DA kg(-1) bw. Furthermore, the mean concentrations (+/- SD) of DA detected by HPLC-UV in extracts of brain after exposure to 9.0 mg DA kg(-1) bw were 0.61 +/- 0.01, 0.96 +/- 0.00, and 0.36 +/- 0.01 mg DA kg(-1) tissue at 1, 2, and 4 hours. The lack of major permanent brain damage in S. aurata, and reversibility of neurotoxic signs, suggest that lower susceptibility to DA or neuronal recovery occurs in affected individuals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12