Desensitization of bladder sensory fibers by intravesical capsaicin has long lasting clinical and urodynamic effects in patients with hyperactive or hypersensitive bladder dysfunction

• Type: Article in International Scientific Journal
• Date: 1997

Authors

Francisco Cruz (Author) FMUP; Miguel Guimarães (Author) Other; Carlos Silva (Author) FMUP; Maria Edite Rio (Author) Other; Coimbra A. (Author) FMUP; Mario Reis (Author) FMUP

Journal

Title: Journal of Urology

Vol. 157 No. 2

Pages: 585-589

ISSN: 0022-5347

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 100 Citations

Scopus - 124 Citations

Pubmed / Medline

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

CORDIS: Health sciences > Medical sciences > Medicine > Urology

Other information

Authenticus ID: P-001-C23

DOI: 10.1016/s0022-5347(01)65211-x

Abstract (EN): Purpose: Capsaicin was used to treat symptomatic patients with hyperactive or hypersensitive bladders. Materials and Methods: Capsaicin solution (1 mM.) was instilled into the bladder of 16 patients with spinal hyperreflexia, bladder instability or hypersensibility. Results: Frequency decreased in 14 patients and continence was achieved in 10 of 14 incontinent cases. Mean first desire to void and maximal cystometric capacity increased significantly. These effects lasted for 6 to 12 months and were renewed following repeat treatment. Conclusions: Bladder afferent desensitization with capsaicin is promising in patients with motor or sensory bladder dysfunction, although initial pungency might limit its use.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5