What is in the pipeline for new treatments for bladder pain syndrome/ interstitial cystitis?

• Type: Another Publication in an International Scientific Journal
• Date: 2024

Authors

Dias, D (Author) Other; Mendes, PA (Author) Other; Paulo Dinis (Author) FMUP; Pinto, RA (Author) Other

Journal

Title: Current Opinion in Urology

Vol. 34

Pages: 58-63

ISSN: 0963-0643

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 0 Citations

Scopus

Other information

Authenticus ID: P-010-0XF

DOI: 10.1097/mou.0000000000001159

Abstract (EN): Purpose of reviewDespite available treatments, many bladder pain syndrome/interstitial cystitis (BPS/IC) patients continue to have poor quality of life. Thus, there is an urge for new therapies. Our manuscript aims to review papers about BPS/IC treatments published in the last 2 years.Recent findingsDuring this period, several treatments were tested, most of them new and others combining treatments already used. Pentosan polysulfate, interleukin 1 antagonist, low energy shock wave, physical therapy, hypnosis, acupuncture, clorpactin, dimethyl sulfoxide and hyaluronic acid plus botulinum toxin-A showed positive results. ASP3652 and lidocaine-releasing intravesical systems failed to prove their efficacy.SummaryValidation of these studies is arduous due to the broad spectre of BPS/IC phenotypes, small number of patients enrolled, distinct outcome measures and short-term follow-up. It is also important to highlight that some authors combined therapies, and others split central and peripheric phenotypes before treatment. Therefore, soon, phenotyping and combining therapies with a step-by-step approach will be needed in BPS/IC treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6