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Synthesis and evaluation of alpha-, beta-glucosidase inhibition of 1-N-carboxamide-1-azafagomines and 5-epi-1-azafagomines

Title
Synthesis and evaluation of alpha-, beta-glucosidase inhibition of 1-N-carboxamide-1-azafagomines and 5-epi-1-azafagomines
Type
Article in International Scientific Journal
Year
2014
Authors
Mendes, R
(Author)
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Duarte, VCM
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Fortes, AG
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Alves, MJ
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Journal
Title: Carbohydrate ResearchImported from Authenticus Search for Journal Publications
Vol. 395
Pages: 52-57
ISSN: 0008-6215
Publisher: Elsevier
Other information
Authenticus ID: P-009-PW7
Abstract (EN): 1-N-Carboxamide 1-azafagomines and 5-epi-1-azafagomines were obtained from 1-azafagomine and 5-epi-1-azafagomine. The hydroxyl groups and the N-2 pyridazine position were protected prior to reaction with different isocyanates to form ureas. Protective groups were removed leading to the target compounds in 18-23% global yields. Final compounds were tested towards alpha- and beta-glucosidases.
Language: English
Type (Professor's evaluation): Scientific
No. of pages: 6
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