Association of trace element status in COVID-19 patients with disease severity

• Type: Article in International Scientific Journal
• Date: 2022

Authors

Bego, T (Author) Other; Meseldzic, N (Author) Other; Prnjavorac, B (Author) Other; Prnjavorac, L (Author) Other; Marjanovic, D (Author) Other; Azevedo, R (Author) Other; Pinto, E (Author) Other; Duro, M (Author) Other; Couto, C (Author) Other; Agostinho Almeida (Author) FFUP

Journal

Title: Journal of Trace Elements in Medicine and Biology

Vol. 74

ISSN: 0946-672X

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 2 Citations

Scopus - 2 Citations

Other information

Authenticus ID: P-00X-2RW

DOI: 10.1016/j.jtemb.2022.127055

Abstract (EN): Caused by the new SARS-CoV-2 coronavirus, COVID-19 (coronavirus disease 2019) evolves with clinical symptoms that vary widely in severity, from mild symptoms to critical conditions, which can even result in the patient's death. A critical aspect related to an individual response to SARS-CoV-2 infection is the competence of the immune system, and it is well known that several trace elements are essential for an adequate immune response and have anti-inflammatory and antioxidant properties that are of particular importance in fighting infection. Thus, it is widely accepted that adequate trace element status can reduce the risk of SARS-CoV-2 infection and disease severity. In this study, we evaluated the serum levels of Cu, Zn, Se, Fe, I and Mg in pa-tients (n = 210) with clinical conditions of different severity ( mild , moderate , severe and exitus letalis , i. e., patients who eventually died). The results showed significant differences between the four groups for Cu, Zn, Se and Fe, in particular a significant trend of Zn and Se serum levels to be decreased and Cu to be increased with the severity of symptoms. For Mg and I, no differences were observed, but I levels were shown to be increased in all groups.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9