Chronic Granulomatous Disease Mimicking Colonic Crohn's Disease Successfully Treated with Infliximab

• Type: Article in International Scientific Journal
• Date: 2017

Authors

Peixoto, A (Author) Other; Coelho, R (Author) Other; Maia, T (Author) Other; Sarmento A (Author) FMUP; Magro, F (Author) Other; Macedo G (Author) FMUP

Journal

Title: ACG Case Reports Journal

Vol. 4

Final page: e46

ISSN: 2326-3253

Publisher: American College of Gastroenterology

Indexing

ISI Web of Knowledge - 4 Citations

Other information

Authenticus ID: P-00N-1HW

DOI: 10.14309/crj.2017.46

Abstract (EN): Chronic granulomatous disease (CGD) is a genetically induced disease caused by mutations in one of the components of the NADPH-oxidase in phagocytes, characterized by life-threatening bacterial and fungal infections and granuloma formation. Treatment includes prevention of infectious complications and immunomodulation. However, a standard strategy is not yet defined. The authors report an X-linked CGD female carrier who presented during adulthood with diarrhea and colorectal ulcers, with high impairment of quality of life. Induction with infliximab 5 mg/kg (weeks 0, 2, and 6) with infectious prophylaxis was initiated. She continued infliximab 5 mg/kg every 8 weeks with complete symptomatic response at 15 months.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3