Expression and prognostic significance of CK19 in canine malignant mammary tumours

• Type: Article in International Scientific Journal
• Date: 2010

Authors

Gama, A (Author) Other; Alves, A (Author) Other; Fernando Schmitt (Author) FMUP

Journal

Title: Veterinary Journal

Vol. 184

Pages: 45-51

ISSN: 1090-0233

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 17 Citations

Scopus - 20 Citations

Other information

Authenticus ID: P-003-861

DOI: 10.1016/j.tvjl.2009.02.001

Abstract (EN): Expression of the luminal cytokeratin CK19 was examined in 102 canine mammary carcinomas by immunohistochemical analysis and associated with known expression of oestrogen receptor (ER), basal/myoepithelial cell markers, proliferation and survival. Negative staining for CK19 was present in 23.5% of tumours and was associated with histological type, grade, invasiveness, Ki67 index and expression of basal/myoepithelial cell markers. Positive staining for CK19 was associated with ER expression. Reduced expression of CK19 was associated with both shorter overall and disease-free survival rates; however, CK19 was not an independent prognostic factor in multivariate analysis. Reduced expression of CK19 in canine mammary carcinomas is related to an aggressive phenotype and may play a role in tumour progression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7