In vivo Bio-Distribution and Toxicity Evaluation of Polymeric and Lipid-Based Nanoparticles: A Potential Approach for Chronic Diseases Treatment

• Type: Article in International Scientific Journal
• Date: 2020

Authors

Fonseca Gomes, J (Author) Other; Joana A Loureiro (Author) FEUP; Tanqueiro, SR (Author) Other; Mouro, FM (Author) Other; Ruivo, P (Author) Other; Carvalho, T (Author) Other; Sebastiao, AM (Author) Other; Diogenes, MJ (Author) Other; Maria do Carmo Pereira (Author) FEUP

Journal

Title: International Journal of Nanomedicine

Vol. 15

Pages: 8609-8621

ISSN: 1176-9114

Publisher: Dove Medical Press

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00T-086

DOI: 10.2147/ijn.s267007

Abstract (EN): Introduction: Nanoparticles (NPs), as drug delivery systems, appear to be a promising tool for prolonged therapeutic strategies as they allow a controlled drug release over time. However, most of the studies found in the literature simply contemplate the use of a single or low number of dosages with low NPs concentrations. In the context of chronic diseases, like Alzheimer's disease, cancer or human immunodeficiency virus (HIV), where the therapeutic scheme is also chronic, studies with numerous repeated dosages are often neglected. Methods: We screened different NPs, polymeric and lipid-based, in a repeated-dose toxicity study, to evaluate the safety and tissue distribution of promising nanocarriers to be used in the treatment of long-lasting diseases. Results: After administrating 24 high concentrated doses of the selected NPs intraperitoneally (i.p.) (3 times a week for 2 months), animals have presented NPs accumulation in different tissues. However, neither toxicity, bodyweight changes nor clinical signs of disease were observed. Discussion: This work demonstrates no general adverse effects upon the studied NPs repeated-dose exposure, indicating the most promising NPs to be used in the different therapeutic circumstances, which may be useful in chronic diseases treatment.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13