Cystitis is associated with TRPVIb-downregulation in rat dorsal root ganglia

• Type: Article in International Scientific Journal
• Date: 2008

Authors

Charrua A. (Author) FCNAUP; reguenga, c (Author) FMUP; Paule, CC (Author) Other; Nagy, I (Author) Other; Francisco Cruz (Author) FMUP; António Avelino Silva (Author) FMUP

Journal

Title: NeuroReport

Vol. 19 No. 15

Pages: 1469-1472

ISSN: 0959-4965

Publisher: Wolters Kluwer Health

Indexing

Scopus - 17 Citations

Other information

Authenticus ID: P-00F-HZ3

DOI: 10.1097/wnr.0b013e32830f1e73

Abstract (EN): The recently identified splice variant of the transient receptor vanilloid type I (TRPVI) molecule, TRPVIb, produces a negative-dominant effect on the responsiveness of theTRPVI channel, which is increased by peripheral inflammatory processes. Here, we studied, using real-time polymerase chain reaction, whether cyclophosphamide injection-evoked cystitis is associated with altered TRPVI/TRPVIb expression in the L5-L6 dorsal root ganglia, which innervate the urinary bladder. We found that while TRPVI mRNA expression was unchanged, the amount of TRPVIb transcript was significantly reduced in L5-L6 dorsal root ganglia during cystitis. These data indicate that peripheral inflammatory events induce changes inTRPVIb expression in primary sensory neurons, which may result in increased responsiveness of the TRPVI channel. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Language: English

Type (Professor's evaluation): Scientific