Synthesis of 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester derivatives

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Fernandes, C (Author) Other; Soares, P (Author) Other; Gaspar, A (Author) Other; Martins, D (Author) Other; Gomes, LR (Author) Other; Low, JN (Author) Other; Fernanda Borges (Author) FCUP

Journal

Title: Tetrahedron Letters

Vol. 57

Pages: 3006-3010

ISSN: 0040-4039

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 7 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-00K-ST7

DOI: 10.1016/j.tetlet.2016.05.096

Abstract (EN): The development of new chemical entities represents an important challenge in pharmaceutical industry, being the use of privileged scaffolds for library design and drug discovery a valuable approach. Among the panoply of privileged structures, our research group has focused its attention on the chromone (4H-benzopyran-4-one) scaffold due to its chemical versatility and ability to bind to multiple targets. With this endeavour we report an expedite two-step procedure for the synthesis of novel 6-aryl/heteroaryl-4-oxo-4H-chromene-2-carboxylic ethyl ester. The new chromones were synthesized by a C-C Suzuki cross-coupling microwave-assisted reaction, using Pd(OAc)(2) as a catalyst, and a classic Claisen condensation followed by an intramolecular cyclization process.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5