A slow acetylator genotype associated with an increased risk of advanced cervical cancer

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Costa, S (Author) Other; Medeiros, R (Author) Other; Vasconcelos, A (Author) Other; Pinto, D (Author) Other; Lopes, C (Author) ICBAS

Journal

Title: Journal of Cancer Research and Clinical Oncology

Vol. 128

Pages: 678-682

ISSN: 0171-5216

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 25 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-000-M7M

DOI: 10.1007/s00432-002-0391-9

Abstract (EN): Purpose: Human papillomavirus (HPV) is the major etiological agent associated with cervical cancer. However, other risk factors have been indicated, including carcinogen exposure, oral contraceptive usage, certain nutritional deficiencies, and genetic factors. N-acetyltransferase 2 (NAT2) has an important role in the metabolism of several carcinogens. NAT2 polymorphism modulates the activity of the enzyme, by activation, via O-acetylation, or through detoxification, via N-acetylation. This case-control study was designed to evaluate the association between NAT2 polymorphism and genetic susceptibility to cervical cancer. Methods: Genomic DNA was obtained from 125 women with advanced cervical cancer and 170 healthy women. PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphisms) was used to analyse two common mutant alleles at NAT2 loci. Results: The NAT2*6/NAT2*6 genotype, which corresponds to a slow acetylator genotype, was found to be associated with a 3.41-fold (95% CI: 1.35-8.94; P = 0.007) increase in the risk of cervical cancer. For the entire case groups the proportion of cervical cancer cases attributable (attributable proportion) to the NAT2*6/NAT2*6 genotype was 10.2%. Conclusions: The results reported in this study suggest that NAT2 polymorphism is a genetic susceptibility factor involved in the carcinogenesis of cervical cancer, and also that the analysis of the allelic profile of populations in different geographic locations may help to understand the incidence of cervical cancer worldwide.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5