| Summary: |
Synthesis and biological evaluation of a great diversity of compounds with potential biological activity, including -dual-stage antimalarial-leads; -bioactive peptides, mainly antimicrobial and cell-penetrating ones; -novel neuroprotective tripeptide analogues of GPE and PLG; -novel rasagilin analogues, novel homoazanucleosides and novel bioactive analogues of vitamin D; - novel amino acid-based surfactants; -Development, and optimization, of new lead compounds (phenolic acids and derivatives, coumarins, chromones, nucleosides and nitrostyrenes) -Development of bio and pharmainformatics tools for lead optimization and ADMET -Evaluation of the physicochemical parameters of potential drugs -Biological screening (antinflammatory, anticancer and neuroprotective activities) and experimental evaluation of ADMET properties -Development of nanotechnology and nanomedicine innovative applications using cyclodextrins, liposomes, polymers and nanotubes 2 To study the formation and the physicochemical characteristics of new polyphenols and their impact on the quality of the food through the identification and isolation of novel compounds in foods such as grapes and olives and their derivatives (oil and wine), and on the other hand. It is also intended to evaluate the bioavailability of some of these compounds in order to assess their real contribution in terms of biological effects. Some of these compounds (derivatives of anthocyanin pigments) may have technological applications as colorants in food industry. We intend to study methods of encapsulation of some of these compounds with a view to their possible technological application, and also evaluate physical-chemical parameters involved in the chromatic properties, the interaction between polyphenols and proteins and carbohydrates that are at the origin of the flavor of food (stringency), and inhibition of certain digestive enzymes. 3. Study of chemical properties of environmental systems (equilibrium and kinetic chemistr  |
Summary
Synthesis and biological evaluation of a great diversity of compounds with potential biological activity, including -dual-stage antimalarial-leads; -bioactive peptides, mainly antimicrobial and cell-penetrating ones; -novel neuroprotective tripeptide analogues of GPE and PLG; -novel rasagilin analogues, novel homoazanucleosides and novel bioactive analogues of vitamin D; - novel amino acid-based surfactants; -Development, and optimization, of new lead compounds (phenolic acids and derivatives, coumarins, chromones, nucleosides and nitrostyrenes) -Development of bio and pharmainformatics tools for lead optimization and ADMET -Evaluation of the physicochemical parameters of potential drugs -Biological screening (antinflammatory, anticancer and neuroprotective activities) and experimental evaluation of ADMET properties -Development of nanotechnology and nanomedicine innovative applications using cyclodextrins, liposomes, polymers and nanotubes 2 To study the formation and the physicochemical characteristics of new polyphenols and their impact on the quality of the food through the identification and isolation of novel compounds in foods such as grapes and olives and their derivatives (oil and wine), and on the other hand. It is also intended to evaluate the bioavailability of some of these compounds in order to assess their real contribution in terms of biological effects. Some of these compounds (derivatives of anthocyanin pigments) may have technological applications as colorants in food industry. We intend to study methods of encapsulation of some of these compounds with a view to their possible technological application, and also evaluate physical-chemical parameters involved in the chromatic properties, the interaction between polyphenols and proteins and carbohydrates that are at the origin of the flavor of food (stringency), and inhibition of certain digestive enzymes. 3. Study of chemical properties of environmental systems (equilibrium and kinetic chemistry, formation and fate of toxic substances), study and bioanalytical applications of the firefly bioluminescence system and other ATP-dependent bioluminescent systems, development of new fluorescent sensors, synthesis of new fluorescent nanomaterials and their coupling to solid matrices. These studies are based on a chemometric approach because it involves the use of experimental design and optimization techniques and multivariate classification, calibration and curve resolution methods. In addition to the studies of environmental and biochemical systems other applications are developed in forensic and pharmaceutical areas 4. Stemming from acquired experience on surface modification, interface lipid enzyme interactions, synthesis of Au nanoparticles and nanorods and construction of molecular recognition nanostructured surfaces, this research group proposes to undergo further studies of the catalytic properties of nanoassemblies, namely within the topics of : -nanoparticle-mediated electron transfer -structure and kinetic properties of SAM modified surfaces -SAMs of nanostructured films of electrochromic materials -development of ultrasensitive SPR and QCM biosensors -phenomena at electrode/RTIL interfaces -metal and film formation in deep eutectic solvents -molecularly imprinted materials in different formats 5. Using the recognized competence of this group in the area of molecular thermodynamics we continue the study of : - the experimental and computational thermochemistry of organic compounds with biological properties or environmental impact and of polyaromatic compounds, t |