Bioinorganic Chemistry
Keywords |
Classification |
Keyword |
OFICIAL |
Chemistry |
Instance: 2019/2020 - 2S ![Requerida a integração com o Moodle Ícone do Moodle](/fcup/pt/imagens/MoodleIcon)
Cycles of Study/Courses
Acronym |
No. of Students |
Study Plan |
Curricular Years |
Credits UCN |
Credits ECTS |
Contact hours |
Total Time |
L:BQ |
108 |
Official Study Plan |
2 |
- |
6 |
56 |
162 |
Teaching language
Portuguese
Objectives
Understand the role of metal ions in biological systems at a molecular level and the basic chemical principles that promote their reactivity. During classes exemples will be given of the importance of bioinorganic chemistry in several fields (pharmacology, medicine, agriculture, metallurgy, veterinary, among others) .
Learning outcomes and competences
Understand the role of metal ions in biological systems, based on their chemical properties.
Working method
Presencial
Program
Lectures:
Mechanisms of reactions of compounds of transition metals.
Bioinorganic Chemistry - general aspects. Metal cation coordination sites in biological systems.
Applications of spectroscopic techniques in Bioinorganic Chemistry.
Brass ions in transportation.
- Transport and storage of iron.
- Transport and storage of dioxygen.
- Electronic transfer. Cytochromes and iron-sulfur centers. Blue copper proteins.
Catalytic processes.
- Base acid catalysis.
- Zinc enzymes.
- Hydrolytic iron enzymes.
- Enzymes involving H2O2 and O2.
- Peroxidases.
- Oxidases.
- Oxygenases.
- Dismutases
- Production of O2 by photochemistry.
- Enzymes involving radicals and alkyc groups
- Enzyme reactions containing cobalamines (B12).
Photosynthesis.
The respiratory chain.
Practical classes:
Case studies that will developed the contents of the lectures; laboratory classes: the aim of the laboratory classes is to integrate concepts from biology and inorganic chemistry by performing experiments that lie at the interface of these two subjects.
Mandatory literature
Wolfgang Kaim, Brigitte Schwederski, Axel Klein; Bioinorganic Chemistry:Inorganic elements in the chemistry of life, WILEY, 2013
Weller, Overton, Rourke, Armstrong; Inorganic Chemistry (6 e), OXFORD, 2014. ISBN: 978-0-19-964182-6
Complementary Bibliography
Dieter Rehder; Bioinorganic Chemistry, OXFORD, 2014
Robert R, Crichton, Ricardo Louro (Eds-); Practical approaches to biological inorganic chemistry, Elsevier, 2013
Robert R. Crichton; Biological Inorganic Chemistry, Elsevier, 2012. ISBN: 978-0-444-53782-9
Rosette M.Roat-Malone; Bioinorganic Chemistry- a short course, John Wiley & Sons , 2002
Teaching methods and learning activities
In the lectures program contents are presented using multimedia resources. The slides presented in the classes will be available on the web page of the course. Internet sites where students can complement their knowledge will also be shown.
In theoretical-practical classes students are invited to solve and report some case studies. At the end of the Laboratory classes: Moodle, students have to make a 15 minutes oral presentation using Powerpoint with audio.
Evaluation Type
Distributed evaluation with final exam
Assessment Components
designation |
Weight (%) |
Exame |
70,00 |
Trabalho laboratorial |
30,00 |
Total: |
100,00 |
Amount of time allocated to each course unit
designation |
Time (hours) |
Estudo autónomo |
106,00 |
Frequência das aulas |
28,00 |
Trabalho laboratorial |
28,00 |
Total: |
162,00 |
Eligibility for exams
Admission to the final exam is only possible for those students that have not missed more than 1/4 of the number of the planned practical classes, have positive grade on at least 2/3 of the practical lab work and that have a final practical classification higher than 9.5.
Calculation formula of final grade
The student is approved to the curricular unit if his final grade (NF) is equal to or greater than 9.5. This UC, given its theoretical and laboratory double nature, has two evaluation components. The evaluation of the theoretical component will be made through continuous evaluation (NT), in which they cannot have a classification of less than 8.0 values, which will have a weight of 70% in the final grade. In order, to be able to be submit to the final exam, students must have a positive practical assessment (NP), which will have a weight of 30% in the final grade.
The evaluation of the theoretical component
Online mini-tests T1, T2, T3: Each mini-test is worth 20% of the theoretical score.
Face-to-face examination (E) (on a date to be scheduled by the CP) is worth 40% of the theoretical score.
NT= 60% (T)+ 40% (E)
The evaluation of the practical component
NP = 20% full report + 40% mini-tests + 40% oral presentation
Final Mark
NF = 70% (NT) + 30% (NP)
Special assessment (TE, DA, ...)
Working students, if they wish not to carry out continuous assessment, may opt for a global exam in the normal time, in which case their theoretical final grade (NT) is equal to the grade obtained in this global exam.
In this case, they must
timely notify, the UC regent.
If these students can not attend the practical component, they must perform a final laboratory examination, on a date to be agreed with the UC regent.
Classification improvement
All students who wish to make grade improvement (a GLOBAL EXAM on the subject taught) after having passed the UC have to register for it in Academic Services.