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Bioinorganic Chemistry

Code: Q2017     Acronym: Q2017     Level: 200

Keywords
Classification Keyword
OFICIAL Chemistry

Instance: 2019/2020 - 2S Ícone do Moodle

Active? Yes
Responsible unit: Department of Chemistry and Biochemistry
Course/CS Responsible: Bachelor in Biochemistry

Cycles of Study/Courses

Acronym No. of Students Study Plan Curricular Years Credits UCN Credits ECTS Contact hours Total Time
L:BQ 108 Official Study Plan 2 - 6 56 162
Mais informaçõesLast updated on 2020-05-06.

Fields changed: Teaching methods and learning activities, Fórmula de cálculo da classificação final, Programa, Obtenção de frequência, Avaliação especial

Teaching language

Portuguese

Objectives

Understand the role of metal ions in biological systems at a molecular level and the basic chemical principles that promote their reactivity. During classes exemples will be given of the importance of bioinorganic chemistry in several fields (pharmacology, medicine, agriculture, metallurgy, veterinary, among others) .

Learning outcomes and competences

Understand the role of metal ions in biological systems, based on their chemical properties.

Working method

Presencial

Program

Lectures:

Mechanisms of reactions of compounds of transition metals.
Bioinorganic Chemistry - general aspects. Metal cation coordination sites in biological systems.
Applications of spectroscopic techniques in Bioinorganic Chemistry.
Brass ions in transportation.
  1. Transport and storage of iron.
  2. Transport and storage of dioxygen.
  3. Electronic transfer. Cytochromes and iron-sulfur centers. Blue copper proteins.
Catalytic processes.
  1. Base acid catalysis.
    1. Zinc  enzymes.
    2. Hydrolytic iron enzymes.
  2. Enzymes involving H2O2 and O2.
    1. Peroxidases.
    2. Oxidases.
    3. Oxygenases.
    4. Dismutases
    5. Production of O2 by photochemistry.
  3. Enzymes involving radicals and alkyc groups
    1. Enzyme reactions containing cobalamines (B12).
Photosynthesis.
The respiratory chain.


Practical classes:
Case studies that will developed the contents of the lectures; laboratory classes: the aim of the laboratory classes is to integrate concepts from biology and inorganic chemistry by performing experiments that lie at the interface of these two subjects. 

Mandatory literature

Wolfgang Kaim, Brigitte Schwederski, Axel Klein; Bioinorganic Chemistry:Inorganic elements in the chemistry of life, WILEY, 2013
Weller, Overton, Rourke, Armstrong; Inorganic Chemistry (6 e), OXFORD, 2014. ISBN: 978-0-19-964182-6

Complementary Bibliography

Dieter Rehder; Bioinorganic Chemistry, OXFORD, 2014
Robert R, Crichton, Ricardo Louro (Eds-); Practical approaches to biological inorganic chemistry, Elsevier, 2013
Robert R. Crichton; Biological Inorganic Chemistry, Elsevier, 2012. ISBN: 978-0-444-53782-9
Rosette M.Roat-Malone; Bioinorganic Chemistry- a short course, John Wiley & Sons , 2002

Teaching methods and learning activities

In the lectures program contents are presented using multimedia resources. The slides presented in the classes will be available on the web page of the course. Internet sites where students can complement their knowledge will also be shown.
In theoretical-practical classes students are invited to solve and report some case studies. At the end of the Laboratory classes: Moodle, students have to make a 15 minutes oral presentation using Powerpoint with audio.

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation Weight (%)
Exame 70,00
Trabalho laboratorial 30,00
Total: 100,00

Amount of time allocated to each course unit

designation Time (hours)
Estudo autónomo 106,00
Frequência das aulas 28,00
Trabalho laboratorial 28,00
Total: 162,00

Eligibility for exams

Admission to the final exam is only possible for those students that have not missed more than 1/4 of the number of the planned practical classes, have positive grade on at least 2/3 of the practical lab work and that have a final practical classification higher than 9.5.

Calculation formula of final grade


The student is approved to the curricular unit if his final grade (NF) is equal to or greater than 9.5. This UC, given its theoretical and laboratory double nature, has two evaluation components. The evaluation of the theoretical component will be made through continuous evaluation (NT), in which they cannot have a classification of less than 8.0 values, which will have a weight of 70% in the final grade. In order, to be able to be submit to the final exam, students must have a positive practical assessment (NP), which will have a weight of 30% in the final grade.


 


The evaluation of the theoretical component


Online mini-tests T1, T2, T3: Each mini-test is worth 20% of the theoretical score.


Face-to-face examination (E) (on a date to be scheduled by the CP) is worth 40% of the theoretical score.


NT= 60% (T)+ 40% (E)



The evaluation of the practical component


NP = 20% full report + 40% mini-tests + 40% oral presentation


Final Mark




NF = 70% (NT) + 30% (NP)


Special assessment (TE, DA, ...)

Working students, if they wish not to carry out continuous assessment, may opt for a global exam in the normal time, in which case their theoretical final grade (NT) is equal to the grade obtained in this global exam.

In this case, they must timely notify, the UC regent.

If these students can not attend the practical component, they must perform a final laboratory examination, on a date to be agreed with the UC regent.

Classification improvement

All students who wish to make grade improvement (a GLOBAL EXAM on the subject taught) after having passed the UC have to register for it in Academic Services.
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