Molecular Bioinformatics

Code:

Q4036

Acronym:

Q4036

Keywords
Classification	Keyword
OFICIAL	Chemistry

Instance: 2018/2019 - 2S

Active?	Yes
Responsible unit:	Department of Chemistry and Biochemistry
Course/CS Responsible:	Bioinformatics and Computational Biology

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
E:BBC	1	PE_Bioinformatics and Computational Biology	1	-	6	42	162
M:BBC	5	The study plan since 2018	1	-	6	42	162

Teaching language

Suitable for English-speaking students

Objectives

General objectives:

The main objective of the lectures is to provide an introductory overview of molecular bioinformatics with focus on its molecular branch. In the practical classes the students will develop small research projects. 

 

Specific objectives:

Expertise in the use of basic molecular bioinformatics tools and software. Expertise in macromolecule modelling. Application of molecular docking in molecular bioinformatics. Characterization of enzyme-inhibitor specific interactions. Capacity for choosing the most adequate molecular bioinformatics tool for each biochemical problem.

Learning outcomes and competences

Expertise in the use of bioinformatic tools and softwares. Capacity to identify bioactive compounds by virtual screening. Expertise in macromolecule modelling. Capacity for choosing the most adequate bioinformatic tool for each biochemical problem.

Working method

Presencial

Program

Lectures: 

1. Protein structure and modelling.
2. Molecular mechanics.
3. Docking protein-ligand.
4. Design of new drugs.
5. Virtual screening. 

 

Practical classes:

The students will develop small research projects

Mandatory literature

Leach Andrew R.; Molecular modelling. ISBN: 0-582-38210-6

Complementary Bibliography

Atkins Peter; Physical chemistry for the life sciences. ISBN: 0-1992-8095-9 (Oxford)
Kuriyan John; The molecules of life. ISBN: 9780815341888
Williamson Michael P. 1957-; How proteins work. ISBN: 978-0-8153-4446-9

Teaching methods and learning activities

Lectures, often including workshops. Practical computational classes, with one student by computer

Evaluation Type

Distributed evaluation with final exam

Assessment Components

designation	Weight (%)
Apresentação/discussão de um trabalho científico	50,00
Exame	50,00
Total:	100,00

Amount of time allocated to each course unit

designation	Time (hours)
Apresentação/discussão de um trabalho científico	24,00
Elaboração de projeto	12,00
Estudo autónomo	70,00
Frequência das aulas	56,00
Total:	162,00

Eligibility for exams

Attendance of 75% of the practical classes and oral presentation of the research work carried out.

Calculation formula of final grade

The final mark corresponds to the average of the mark obtained in the exam and the mark given in the practical classes and corresponding report made by the student.

The mark obtained in the exam mostly reflects the result of the final exam, which is scheduled by the Conselho Pedagógico of the Faculty. The weight of the exam for the final mark is 50%.

The practical mark is the result of a oral presentation of the research work carried out. in the practical classes. Its weight for the final mark is 50%.