Code: | Q254 | Acronym: | Q254 |
Keywords | |
---|---|
Classification | Keyword |
OFICIAL | Chemistry |
Active? | Yes |
Responsible unit: | Department of Chemistry and Biochemistry |
Course/CS Responsible: | Bachelor in Chemistry |
Acronym | No. of Students | Study Plan | Curricular Years | Credits UCN | Credits ECTS | Contact hours | Total Time |
---|---|---|---|---|---|---|---|
L:Q | 51 | Plano de estudos Oficial | 2 | - | 5 | - |
Study of the physical, chemical and biological properties of proteins and DNA. Principles of enzymatic catalysis. Use of computational techniques to the study and prediction of the properties of proteins and DNA.
- By the end of this course, students will be aware of the fact that fundamental chemical and physical principles also apply to complex biological systems.
- By the end of this course, students will be able to describe the structure and properties of all the amino acids that include the natural proteins.
- By the end of this course, students will be familiar with the molecular structure of proteins and the 3D motifs they adopt at each level of structure organization.
- By the end of this course, students will be able to describe all kinds of functions of proteins in living organisms.
- By the end of this course, students will understand that protein structure is related to function.
- By the end of this course, students will understand the basic principles of catalytic action of enzymes and their interaction with substrates.
- By the end of this course, students will be able to describe the molecular structure of DNA and the basis of replication.
- By the end of this course, students will be able to understand a few common interactions between DNA and proteins.
- By the end of this course, students will be able to understand the basic principles of Molecular Dynamics, to perform simple simulations on small protein systems using the Amber software, and to interpret the results.
- By the end of this course, students will be familiar with the PDB-Protein Data Bank, and with the necessary computational tools to retrieve information from it.
- By the end of this course, students will be able to manipulate protein molecular models within the specific software VMD-Visual Molecular Dynamics.
THEORETICAL CLASSES 1. Molecular interaction in biological systems. 2. Biomolecules- chemistry and structure. 3.From amino acids to Proteins. 4. Primary, Secondary, Tertiary and Quaternary Structure of Proteins 5. Computational Visualization of proteins. 6. Enzymatic Catalysis and Inhibition. 7. Nucleic Acids.
PRACTICAL CLASSES I. Introduction to Linux OS. II. Scientific information and data - PDB (protein databank) - research articles (Web of science) - Web tools to analyze pdb data and structures III. Basics of the visualization of molecules (software VMD) IV. Study and graphical visualization of Amino acids and Proteins V. Molecular Dynamics simulation of the interaction between an enzyme and substrate. (software: Amber ; VMD)
Theoretical lessons complemented with computational sessions using specific software in Linux environment.
Description | Type | Time (hours) | Weight (%) | End date |
---|---|---|---|---|
Attendance (estimated) | Participação presencial | 56,00 | 0,00 | |
Teste | 25,00 | |||
Teste | 25,00 | |||
Exame | 50,00 | |||
Total: | - | 100,00 |
Description | Type | Time (hours) | End date |
---|---|---|---|
Trabalho laboratorial | 12 | ||
Total: | 12,00 |
The students must attend at least 75% of the practical classes.
Final grade =50%PE + 50%EX PE- arithmetic mean of the two practical evaluations planned for the semester. EX- Final Theoretical Exam Both evaluations marks (PE and EX) should not be less than 7,0 ( in 20 ).
.
.
The student can repeat the final theoretical exam on the date and under the rules defined by the Conselho Pedagógico of the Faculty of Sciences of Porto.