miR signatures and the role of miRs in acute myeloid leukaemia

• Type: Another Publication in an International Scientific Journal
• Date: 2010

Authors

Hugo Seca (Author) Other; Gabriela M Almeida (Author) Other; Jose E Guimaraes (Author) FMUP; Helena Vasconcelos, MH (Author) FFUP

Journal

Title: European Journal of Cancer

Vol. 46 No. 9

Pages: 1520-1527

ISSN: 0959-8049

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 32 Citations

Scopus - 32 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-003-61H

DOI: 10.1016/j.ejca.2010.03.031

Abstract (EN): Acute myeloid leukaemia (AML) is a hematopoietic stem cell disorder in which neoplastic myeloblasts are arrested in an immature stage of differentiation. Recent publications have underlined the involvement of non-coding RNAs in cancer and particularly in AML development, with several studies regarding their possible contribution to the evolution of the disease. MicroRNAs (miRs) are a class of single-stranded non-coding RNAs that bind to the 3'-untranslated region of target mRNAs and thus negatively regulate gene expression, by translation repression or mRNA degradation. Abnormal expression of miRs in AML has been described and we here review the current data from miR expression profiles. Additionally, we review the current knowledge on the biological function of individual miRs in the development of AML.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8