Cosmetic outcome after intraoperative radiotherapy or external beam radiotherapy for early breast cancer: An objective assessment of patients from a randomized controlled trial.

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Keshtgar, Mohammed R. (Author) Other; Williams, Norman R. (Author) Other; Corica, Tammy (Author) Other; Bulsara, Max (Author) Other; Saunders, Christobel (Author) Other; Flyger, Henrik (Author) Other; Bentzon, Neils (Author) Other; Jaime Cardoso (Author) FEUP; Michalopoulos, Nikolaus (Author) Other; Joseph, David John (Author) Other

Journal

Title: Journal of Clinical Oncology

Vol. 31 No. 26, S

Pages: 1110-1110

ISSN: 0732-183X

Publisher: American Society of Clinical Oncology

Indexing

ISI Web of Knowledge

ISI Web of Science

Scientific classification

FOS: Engineering and technology > Electrical engineering, Electronic engineering, Information engineering

CORDIS: Technological sciences > Engineering > Biomedical enginnering

Other information

Authenticus ID: P-00X-G02

DOI: 10.1200/jco.2013.31.15_suppl.1110

Abstract (EN): <jats:p> 1110 </jats:p><jats:p> Background: The international randomised contolled TARGeted Intraoperative radioTherapy (TARGIT) trial has demonstrated non-inferiority between the novel technique of TARGIT (intra-operative radiotherapy with Intrabeam) and conventional whole-breast external beam radiotherapy (EBRT) in women with early breast cancer, in terms of the primary outcome measure of risk of local relapse within the treated breast. With very low recurrence rates, cosmesis becomes an increasingly important outcome of breast conserving treatment with both surgery and radiotherapy. This study was performed to determine if the single high dose of TARGIT leads to impaired cosmesis. Methods: A validated, objective assessment tool for evaluation of cosmetic outcome was used. Frontal digital photographs were taken at baseline (before TARGIT or EBRT) and yearly thereafter for up to five years. The photographs were analysed by BCCT.core software which produces a composite score based on symmetry, colour and scar. Results: 342 patients were assessed, all over 50 years old with a median age at baseline of 64 years (IQR 59 to 68). The scores were dichotomised into Excellent and Good (EG), and Fair and Poor (FP). There were statistically significant increases in the odds of having an outcome of EG for patients in the TARGIT group relative to the EBRT group at year 1 (OR = 2.07, 95%CI 1.12 to 3.85, p = 0.021) and year 2 (OR = 2.11, 95%CI 1.0 to 4.45, p = 0.05). Conclusions: Following an objective assessment of aesthetic outcome in patients from a randomised setting, this study demonstrates that those treated with targeted intraoperative radiotherapy have a superior cosmetic result compared with those patients who received conventional whole-breast external beam radiotherapy. </jats:p>

Language: English

Type (Professor's evaluation): Scientific